EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors

INTRODUCTION: The EGFR-A763_Y764insFQEA is a unique exon 20 insertion mutation (∼5% to 6% of exon 20 insertions), which, at the structural and enzyme kinetic level, more closely resembles EGFR tyrosine kinase inhibitor (TKI)–sensitizing mutants, such as EGFR exon 19 indels and L858R. A limited numbe...

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Detalhes bibliográficos
Publicado no:JTO Clin Res Rep
Main Authors: Vasconcelos, Pedro E.N.S., Gergis, Carol, Viray, Hollis, Varkaris, Andreas, Fujii, Masanori, Rangachari, Deepa, VanderLaan, Paul A., Kobayashi, Ikei S., Kobayashi, Susumu S., Costa, Daniel B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183979/
https://ncbi.nlm.nih.gov/pubmed/34104899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtocrr.2020.100051
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