Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

Inactivation of the von Hippel–Lindau tumour suppressor in renal cell carcinoma (RCC) leads to failure of proteolytic regulation of the α subunits of hypoxia-inducible factor (HIF), constitutive upregulation of the HIF complex, and overexpression of HIF target genes. However, recent studies have ind...

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Bibliografiske detaljer
Main Authors: Lau, K W, Tian, Y-M, Raval, R R, Ratcliffe, P J, Pugh, C W
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360163/
https://ncbi.nlm.nih.gov/pubmed/17387348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603675
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