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Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: antitumour supra-additive effects on human head and neck cancer xenografts

The aim of this study was to investigate the effects of combining antiangiogenic treatment, epidermal growth factor receptor (EGFR) targeting and irradiation (RT). We evaluated AZD2171, a highly potent, orally active, vascular endothelial growth factor (VEGF) signalling inhibitor, gefitinib, an EGFR...

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Autors principals: Bozec, A, Formento, P, Lassalle, S, Lippens, C, Hofman, P, Milano, G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359670/
https://ncbi.nlm.nih.gov/pubmed/17592499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603791
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