Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma

BACKGROUND: The epidermal growth factor receptor (EGFR)-targeted therapies have been tested in the clinic as treatments for head and neck squamous cell carcinoma (HNSCC). Owing to intrinsic or acquired resistance, EGFR-targeted therapies often lead to a low response rate and treatment failure. Inter...

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Vydáno v:Br J Cancer
Hlavní autoři: Ma, Hailong, Jin, Shufang, Yang, Wenyi, Zhou, Ge, Zhao, Mei, Fang, Sijie, Zhang, Zhiyuan, Hu, Jingzhou
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2018
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830595/
https://ncbi.nlm.nih.gov/pubmed/29348488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.442
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