Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy

BACKGROUND: The development of a safe and effective AD vaccine requires a delicate balance between providing an adequate anti-Aβ antibody response sufficient to provide therapeutic benefit, while eliminating an adverse T cell-mediated proinflammatory autoimmune response. To achieve this goal we have...

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Détails bibliographiques
Auteurs principaux: Movsesyan, Nina, Ghochikyan, Anahit, Mkrtichyan, Mikayel, Petrushina, Irina, Davtyan, Hayk, Olkhanud, Purevdorj B., Head, Elizabeth, Biragyn, Arya, Cribbs, David H., Agadjanyan, Michael G.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2358976/
https://ncbi.nlm.nih.gov/pubmed/18461171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002124
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