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2-Deoxyglucose combined with wild type p53 over expression enhances cytotoxicity in human prostate cancer cells via oxidative stress

Over expression of the tumor suppressor gene, wild type p53 (wtp53), using adenoviral vectors (Adp53) has been suggested to kill cancer cells by hydroperoxide-mediated oxidative stress [1, 2] and nutrient distress induced by the glucose analog, 2-deoxyglucose (2DG), has been suggested to enhance tum...

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Détails bibliographiques
Auteurs principaux: Ahmad, Iman M., Abdalla, Maher Y., Aykin-Burns, Nukhet, Simons, Andrean L., Oberley, Larry W., Domann, Frederick E., Spitz, Douglas R.
Format: Artigo
Langue:Inglês
Publié: 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2350201/
https://ncbi.nlm.nih.gov/pubmed/18155176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.11.007
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