The p53/p21(WAF/CIP) Pathway Mediates Oxidative Stress and Senescence in Dyskeratosis Congenita Cells with Telomerase Insufficiency

Telomere attrition is a natural process that occurs due to inadequate telomere maintenance. Once at a critically short threshold, telomeres signal growth arrest, leading to senescence. Telomeres can be elongated by the enzyme telomerase, which adds de novo telomere repeats to the ends of chromosomes...

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Detalhes bibliográficos
Main Authors: Westin, Erik R., Aykin-Burns, Nukhet, Buckingham, Erin M., Spitz, Douglas R., Goldman, Frederick D., Klingelhutz, Aloysius J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043957/
https://ncbi.nlm.nih.gov/pubmed/21087144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3444
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