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2-Deoxyglucose combined with wild type p53 over expression enhances cytotoxicity in human prostate cancer cells via oxidative stress

Over expression of the tumor suppressor gene, wild type p53 (wtp53), using adenoviral vectors (Adp53) has been suggested to kill cancer cells by hydroperoxide-mediated oxidative stress [1, 2] and nutrient distress induced by the glucose analog, 2-deoxyglucose (2DG), has been suggested to enhance tum...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ahmad, Iman M., Abdalla, Maher Y., Aykin-Burns, Nukhet, Simons, Andrean L., Oberley, Larry W., Domann, Frederick E., Spitz, Douglas R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2350201/
https://ncbi.nlm.nih.gov/pubmed/18155176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.11.007
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