Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes

Cells infected with human cytomegalovirus in the absence of UL97 kinase activity produce large nuclear aggregates that sequester considerable quantities of viral proteins. A transient expression assay suggested that pp71 and IE1 were also involved in this process, and this suggestion was significant...

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Autori principali: Prichard, Mark N., Sztul, Elizabeth, Daily, Shannon L., Perry, Amie L., Frederick, Samuel L., Gill, Rachel B., Hartline, Caroll B., Streblow, Daniel N., Varnum, Susan M., Smith, Richard D., Kern, Earl R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346732/
https://ncbi.nlm.nih.gov/pubmed/18321963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02174-07
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