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Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes

Cells infected with human cytomegalovirus in the absence of UL97 kinase activity produce large nuclear aggregates that sequester considerable quantities of viral proteins. A transient expression assay suggested that pp71 and IE1 were also involved in this process, and this suggestion was significant...

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Bibliografiska uppgifter
Huvudupphovsmän: Prichard, Mark N., Sztul, Elizabeth, Daily, Shannon L., Perry, Amie L., Frederick, Samuel L., Gill, Rachel B., Hartline, Caroll B., Streblow, Daniel N., Varnum, Susan M., Smith, Richard D., Kern, Earl R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346732/
https://ncbi.nlm.nih.gov/pubmed/18321963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02174-07
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