Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir

The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb) and has three consensus Rb-binding motifs that might contribute to this activity. Recombinant viruses containing mutations in the Rb-binding motifs generally replicated well in human foreskin fibroblasts w...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gill, Rachel B, Frederick, Samuel L, Hartline, Caroll B, Chou, Sunwen, Prichard, Mark N
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636770/
https://ncbi.nlm.nih.gov/pubmed/19159461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-6-9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares