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Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir

The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb) and has three consensus Rb-binding motifs that might contribute to this activity. Recombinant viruses containing mutations in the Rb-binding motifs generally replicated well in human foreskin fibroblasts w...

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Autori principali: Gill, Rachel B, Frederick, Samuel L, Hartline, Caroll B, Chou, Sunwen, Prichard, Mark N
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636770/
https://ncbi.nlm.nih.gov/pubmed/19159461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-6-9
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