In vitro selection of self-cleaving RNAs with a low pH optimum
RNAs that undergo a rapid site-specific cleavage at low pH have been selected by in vitro selection (the SELEX process). The cleavage does not require the addition of any divalent metal ions, and is in fact inhibited by divalent metal ions, spermine, or high concentrations of monovalent metal ions....
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1997
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23421/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10612 |
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