Position-Dependent Stabilization of DNA/RNA Duplexes by Site-Specific Incorporation of LNA Nucleosides

Owing to their enhanced functional properties, 2′,4′-bridged nucleic acids/locked nucleic acids (2′,4′-BNAs/LNAs) are considered promising candidates for antisense oligonucleotide therapeutics. The spatial arrangement of LNA residues within the oligonucleotide sequence is a key determinant of bindin...

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主要な著者:	Elisa Tomita-Sudo, Tomoka Akita, Nae Sakimoto, Saori Tahara-Takamine, Renshin Sano, Shigenori Iwai, Junji Kawakami
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2026-01-01
シリーズ:	Journal of Nucleic Acids
オンライン･アクセス:	http://dx.doi.org/10.1155/jna/7266073
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