Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP

Recently, the US Food and Drug Administration (FDA) approved the first small interfering RNA (siRNA) drug, marking a significant milestone in the therapeutic use of RNA interference (RNAi) technology. However, off-target gene silencing by siRNA remains one of the major obstacles in siRNA therapy. Al...

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Үндсэн зохиолчид:	Yao Zhang, Yilan Teng, Wangwen Xiao, Beiying Xu, Ya Zhao, Weihua Li, Ligang Wu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2020-12-01
Цуврал:	Molecular Therapy: Nucleic Acids
Нөхцлүүд:	RNAi siRNA miRNA off-target CLIP SpyTag
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2162253120303218
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!