Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP

Recently, the US Food and Drug Administration (FDA) approved the first small interfering RNA (siRNA) drug, marking a significant milestone in the therapeutic use of RNA interference (RNAi) technology. However, off-target gene silencing by siRNA remains one of the major obstacles in siRNA therapy. Al...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yao Zhang, Yilan Teng, Wangwen Xiao, Beiying Xu, Ya Zhao, Weihua Li, Ligang Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-12-01
Colecção:	Molecular Therapy: Nucleic Acids
Assuntos:	RNAi siRNA miRNA off-target CLIP SpyTag
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2162253120303218
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!