The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells

Hematopoietic stem cells (HSCs) are multipotent progenitors that give rise to all types of blood cells. In the present study, we document that HSC development and functions are negatively regulated by the E3 ubiquitin ligase c-Cbl (casitas B-cell lymphoma). HSCs of c-Cbl(−/−) mice exhibit augmented...

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Autors principals: Rathinam, Chozhavendan, Thien, Christine B.F., Langdon, Wallace Y., Gu, Hua, Flavell, Richard A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335331/
https://ncbi.nlm.nih.gov/pubmed/18413713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1651408
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