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The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells
Hematopoietic stem cells (HSCs) are multipotent progenitors that give rise to all types of blood cells. In the present study, we document that HSC development and functions are negatively regulated by the E3 ubiquitin ligase c-Cbl (casitas B-cell lymphoma). HSCs of c-Cbl(−/−) mice exhibit augmented...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2335331/ https://ncbi.nlm.nih.gov/pubmed/18413713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1651408 |
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