Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

The scrapie prion protein (PrP(Sc)) is the major, and possibly the only, component of the infectious prion; it is generated from the cellular isoform (PrP(C)) by a conformational change. N-terminal truncation of PrP(Sc) by limited proteolysis produces a protein of ≈142 residues designated PrP 27–30,...

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Autori principali: James, Thomas L., Liu, He, Ulyanov, Nikolai B., Farr-Jones, Shauna, Zhang, Hong, Donne, David G., Kaneko, Kiyotoshi, Groth, Darlene, Mehlhorn, Ingrid, Prusiner, Stanley B., Cohen, Fred E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC23313/
https://ncbi.nlm.nih.gov/pubmed/9294167
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