Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

Fibrillar protein deposits (amyloid) in the pancreatic islets of Langerhans are thought to be involved in death of the insulin-producing islet β cells in type 2 diabetes mellitus. It has been suggested that the mechanism of this β cell death involves membrane disruption by human islet amyloid polype...

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Main Authors: Engel, Maarten F. M., Khemtémourian, Lucie, Kleijer, Cécile C., Meeldijk, Hans J. D., Jacobs, Jet, Verkleij, Arie J., de Kruijff, Ben, Killian, J. Antoinette, Höppener, Jo W. M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329711/
https://ncbi.nlm.nih.gov/pubmed/18408164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708354105
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