Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability.

Telomerase synthesizes telomeric DNA by copying the template sequence of its own RNA component. In Tetrahymena thermophila and yeast (G. Yu, J. D. Bradley, L. D. Attardi, and E. H. Blackburn, Nature 344:126-131, 1990; M. McEachern and E. H. Blackburn, Nature 376:403-409, 1995), mutations in the temp...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Marusíc, L, Anton, M, Tidy, A, Wang, P, Villeponteau, B, Bacchetti, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.11.6394
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