Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability.

Telomerase synthesizes telomeric DNA by copying the template sequence of its own RNA component. In Tetrahymena thermophila and yeast (G. Yu, J. D. Bradley, L. D. Attardi, and E. H. Blackburn, Nature 344:126-131, 1990; M. McEachern and E. H. Blackburn, Nature 376:403-409, 1995), mutations in the temp...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Marusíc, L, Anton, M, Tidy, A, Wang, P, Villeponteau, B, Bacchetti, S
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 1997
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.11.6394
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