Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability.

Telomerase synthesizes telomeric DNA by copying the template sequence of its own RNA component. In Tetrahymena thermophila and yeast (G. Yu, J. D. Bradley, L. D. Attardi, and E. H. Blackburn, Nature 344:126-131, 1990; M. McEachern and E. H. Blackburn, Nature 376:403-409, 1995), mutations in the temp...

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I whakaputaina i:	Mol Cell Biol
Ngā kaituhi matua:	Marusíc, L, Anton, M, Tidy, A, Wang, P, Villeponteau, B, Bacchetti, S
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Taylor & Francis 1997
Ngā marau:	Research Article
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.11.6394
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