Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability.

Telomerase synthesizes telomeric DNA by copying the template sequence of its own RNA component. In Tetrahymena thermophila and yeast (G. Yu, J. D. Bradley, L. D. Attardi, and E. H. Blackburn, Nature 344:126-131, 1990; M. McEachern and E. H. Blackburn, Nature 376:403-409, 1995), mutations in the temp...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Marusíc, L, Anton, M, Tidy, A, Wang, P, Villeponteau, B, Bacchetti, S
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1997
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.11.6394
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