Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability.

Telomerase synthesizes telomeric DNA by copying the template sequence of its own RNA component. In Tetrahymena thermophila and yeast (G. Yu, J. D. Bradley, L. D. Attardi, and E. H. Blackburn, Nature 344:126-131, 1990; M. McEachern and E. H. Blackburn, Nature 376:403-409, 1995), mutations in the temp...

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Publikašuvnnas:	Mol Cell Biol
Váldodahkkit:	Marusíc, L, Anton, M, Tidy, A, Wang, P, Villeponteau, B, Bacchetti, S
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Taylor & Francis 1997
Fáttát:	Research Article
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.11.6394
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