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Antimalarial Quinolones: Synthesis, potency, and mechanistic studies
In the present article we examine the antiplasmodial activities of novel quinolone derivatives bearing extended alkyl or alkoxy side chains terminated by a trifluoromethyl group. In the series under investigation, the IC(50) values ranged from 1.2 to ≈ 30 nM against chloroquine-sensitive and multidr...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323441/ https://ncbi.nlm.nih.gov/pubmed/18082162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2007.10.016 |
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