Optimization of Xanthones for Antimalarial Activity: the 3,6-Bis-ω-Diethylaminoalkoxyxanthone Series

Hydroxyxanthones have been identified as novel antimalarial agents. The compounds are believed to exert their activity by complexation to heme and inhibition of hemozoin formation. Modification of the xanthone structure was pursued to improve their antimalarial activity. Attachment of R-groups beari...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Kelly, Jane Xu, Winter, Rolf, Peyton, David H., Hinrichs, David J., Riscoe, Michael
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11751125/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.1.144-150.2002
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