Optimization of Xanthones for Antimalarial Activity: the 3,6-Bis-ω-Diethylaminoalkoxyxanthone Series

Hydroxyxanthones have been identified as novel antimalarial agents. The compounds are believed to exert their activity by complexation to heme and inhibition of hemozoin formation. Modification of the xanthone structure was pursued to improve their antimalarial activity. Attachment of R-groups beari...

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Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Kelly, Jane Xu, Winter, Rolf, Peyton, David H., Hinrichs, David J., Riscoe, Michael
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2002
Onderwerpen:	Experimental Therapeutics
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11751125/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.1.144-150.2002
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