Optimization of Xanthones for Antimalarial Activity: the 3,6-Bis-ω-Diethylaminoalkoxyxanthone Series

Hydroxyxanthones have been identified as novel antimalarial agents. The compounds are believed to exert their activity by complexation to heme and inhibition of hemozoin formation. Modification of the xanthone structure was pursued to improve their antimalarial activity. Attachment of R-groups beari...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Kelly, Jane Xu, Winter, Rolf, Peyton, David H., Hinrichs, David J., Riscoe, Michael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11751125/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.1.144-150.2002
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