Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.

Activation of the Raf serine/threonine protein kinases is tightly regulated by multiple phosphorylation events. Phosphorylation of either tyrosine 340 or 341 in the catalytic domain of Raf-1 has been previously shown to induce the ability of the protein kinase to phosphorylate MEK. By using a combin...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Diaz, B, Barnard, D, Filson, A, MacDonald, S, King, A, Marshall, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234708/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4509
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