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Regulation of Raf-1 activation and signalling by dephosphorylation

The Raf-1 kinase is regulated by phosphorylation, and Ser259 has been identified as an inhibitory phosphorylation site. Here we show that the dephosphorylation of Ser259 is an essential part of the Raf-1 activation process, and further reveal the molecular role of Ser259. The fraction of Raf-1 that...

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Detalhes bibliográficos
Main Authors: Dhillon, Amardeep S., Meikle, Sharon, Yazici, Zihni, Eulitz, Manfred, Kolch, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125807/
https://ncbi.nlm.nih.gov/pubmed/11782426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.1.64
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