Regulation of Raf-1 activation and signalling by dephosphorylation
The Raf-1 kinase is regulated by phosphorylation, and Ser259 has been identified as an inhibitory phosphorylation site. Here we show that the dephosphorylation of Ser259 is an essential part of the Raf-1 activation process, and further reveal the molecular role of Ser259. The fraction of Raf-1 that...
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| Опубликовано в:: | EMBO J |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125807/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.1.64 |
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