Regulation of Raf-1 activation and signalling by dephosphorylation

The Raf-1 kinase is regulated by phosphorylation, and Ser259 has been identified as an inhibitory phosphorylation site. Here we show that the dephosphorylation of Ser259 is an essential part of the Raf-1 activation process, and further reveal the molecular role of Ser259. The fraction of Raf-1 that...

Popoln opis

Bibliografske podrobnosti

izdano v:	EMBO J
Principais autores:	Dhillon, Amardeep S., Meikle, Sharon, Yazici, Zihni, Eulitz, Manfred, Kolch, Walter
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 2002
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125807/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.1.64
Oznake:	Označite Brez oznak, prvi označite!