Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

The mammalian double-stranded RNA-activated protein kinase PKR is a component of the cellular antiviral defense mechanism and phosphorylates Ser-51 on the alpha subunit of the translation factor eIF2 to inhibit protein synthesis. To identify the molecular determinants that specify substrate recognit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kawagishi-Kobayashi, M, Silverman, J B, Ung, T L, Dever, T E
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1997
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC232268/
https://ncbi.nlm.nih.gov/pubmed/9199350
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