Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

The human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein synthesis by phosphorylating translation initiation factor 2α (eIF2α). Vaccinia virus E3L encodes a dsRNA binding protein that inhibits PKR in virus-infected cells, presumably by sequestering dsRNA activators. Expres...

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Main Authors: Romano, Patrick R., Zhang, Fan, Tan, Seng-Lai, Garcia-Barrio, Minerva T., Katze, Michael G., Dever, Thomas E., Hinnebusch, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
Assuntos:
Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC109312/
https://ncbi.nlm.nih.gov/pubmed/9819417
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