Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

The human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein synthesis by phosphorylating translation initiation factor 2α (eIF2α). Vaccinia virus E3L encodes a dsRNA binding protein that inhibits PKR in virus-infected cells, presumably by sequestering dsRNA activators. Expres...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Romano, Patrick R., Zhang, Fan, Tan, Seng-Lai, Garcia-Barrio, Minerva T., Katze, Michael G., Dever, Thomas E., Hinnebusch, Alan G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1998
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9819417/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.12.7304
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