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The effect of the vaccinia K1 protein on the PKR-eIF2α pathway in RK13 and HeLa cells

Activated PKR protein regulates downstream anti-viral effects, including inhibition of translation. Thus, many viruses encode proteins to inhibit PKR. Here, we provide evidence that the vaccinia virus K1 protein, a host range protein, possesses this function. First, the expression of the wild-type K...

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Detalhes bibliográficos
Main Authors: Willis, Kristen L., Patel, Samir, Xiang, Yan, Shisler, Joanna L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767412/
https://ncbi.nlm.nih.gov/pubmed/19744687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.08.020
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