An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B(1) adducts in a p53 mutational hotspot

Aflatoxin B(1) (AFB(1)) is a potent human carcinogen implicated in the etiology of hepatocellular carcinoma. Upon metabolic activation to the reactive epoxide, AFB(1) forms DNA adducts primarily at the N7 position of guanines. To elucidate more fully the molecular mechanism of AFB(1)-induced mutagen...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kobertz, William R., Wang, David, Wogan, Gerald N., Essigmann, John M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275165/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9579
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