An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B(1) adducts in a p53 mutational hotspot
Aflatoxin B(1) (AFB(1)) is a potent human carcinogen implicated in the etiology of hepatocellular carcinoma. Upon metabolic activation to the reactive epoxide, AFB(1) forms DNA adducts primarily at the N7 position of guanines. To elucidate more fully the molecular mechanism of AFB(1)-induced mutagen...
-д хадгалсан:
| -д хэвлэсэн: | Proc Natl Acad Sci U S A |
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| Үндсэн зохиолчид: | , , , |
| Формат: | Artigo |
| Хэл сонгох: | Inglês |
| Хэвлэсэн: |
National Academy of Sciences
1997
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| Нөхцлүүд: | |
| Онлайн хандалт: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275165/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9579 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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