An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B(1) adducts in a p53 mutational hotspot

Aflatoxin B(1) (AFB(1)) is a potent human carcinogen implicated in the etiology of hepatocellular carcinoma. Upon metabolic activation to the reactive epoxide, AFB(1) forms DNA adducts primarily at the N7 position of guanines. To elucidate more fully the molecular mechanism of AFB(1)-induced mutagen...

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Detaylı Bibliyografya

Yayımlandı:	Proc Natl Acad Sci U S A
Asıl Yazarlar:	Kobertz, William R., Wang, David, Wogan, Gerald N., Essigmann, John M.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	National Academy of Sciences 1997
Konular:	Biological Sciences
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275165/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9579
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