Targeted disruption of the mouse topoisomerase I gene by camptothecin selection.

Topoisomerase I has ubiquitous roles in important cellular functions such as replication, transcription, and recombination. In order to further characterize this enzyme in vivo, we have used gene targeting to inactivate the mouse Top-1 gene. A selection protocol using the topoisomerase I inhibitor c...

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Bibliografiske detaljer
Main Authors: Morham, S G, Kluckman, K D, Voulomanos, N, Smithies, O
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC231683/
https://ncbi.nlm.nih.gov/pubmed/8943335
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