Negative regulation of Raf-1 by phosphorylation of serine 621.
The elevation of cyclic AMP (cAMP) levels in the cell downregulates the activity of the Raf-1 kinase. It has been suggested that this effect is due to the activation of cAMP-dependent protein kinase (PKA), which can directly phosphorylate Raf-1 in vitro. In this study, we confirmed this hypothesis b...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231540/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816453/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.10.5409 |
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