Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.

Here we investigate the role of the Raf-1 kinase in transformation by the v-abl oncogene. Raf-1 can activate a transforming signalling cascade comprising the consecutive activation of Mek and extracellular-signal-regulated kinases (Erks). In v-abl-transformed cells the endogenous Raf-1 protein was p...

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Библиографические подробности
Главные авторы: Weissinger, E M, Eissner, G, Grammer, C, Fackler, S, Haefner, B, Yoon, L S, Lu, K S, Bazarov, A, Sedivy, J M, Mischak, H, Kolch, W
Формат: Artigo
Язык:Inglês
Опубликовано: 1997
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC232176/
https://ncbi.nlm.nih.gov/pubmed/9154822
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