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Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.

Here we investigate the role of the Raf-1 kinase in transformation by the v-abl oncogene. Raf-1 can activate a transforming signalling cascade comprising the consecutive activation of Mek and extracellular-signal-regulated kinases (Erks). In v-abl-transformed cells the endogenous Raf-1 protein was p...

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Publicat a:Mol Cell Biol
Autors principals: Weissinger, E M, Eissner, G, Grammer, C, Fackler, S, Haefner, B, Yoon, L S, Lu, K S, Bazarov, A, Sedivy, J M, Mischak, H, Kolch, W
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232176/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9154822/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.6.3229
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