Negative regulation of Raf-1 by phosphorylation of serine 621.

The elevation of cyclic AMP (cAMP) levels in the cell downregulates the activity of the Raf-1 kinase. It has been suggested that this effect is due to the activation of cAMP-dependent protein kinase (PKA), which can directly phosphorylate Raf-1 in vitro. In this study, we confirmed this hypothesis b...

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Publicado en:	Mol Cell Biol
Autores principales:	Mischak, H, Seitz, T, Janosch, P, Eulitz, M, Steen, H, Schellerer, M, Philipp, A, Kolch, W
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231540/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816453/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.10.5409
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