Negative regulation of Raf-1 by phosphorylation of serine 621.

The elevation of cyclic AMP (cAMP) levels in the cell downregulates the activity of the Raf-1 kinase. It has been suggested that this effect is due to the activation of cAMP-dependent protein kinase (PKA), which can directly phosphorylate Raf-1 in vitro. In this study, we confirmed this hypothesis b...

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Huvudupphovsmän: Mischak, H, Seitz, T, Janosch, P, Eulitz, M, Steen, H, Schellerer, M, Philipp, A, Kolch, W
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1996
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC231540/
https://ncbi.nlm.nih.gov/pubmed/8816453
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