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Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.

Activation of telomerase in human cancers is thought to be necessary to overcome the progressive loss of telomeric DNA that accompanies proliferation of normal somatic cells. According to this model, telomerase provides a growth advantage to cells in which extensive terminal sequence loss threatens...

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Udgivet i:Mol Cell Biol
Principais autores: Broccoli, D, Godley, L A, Donehower, L A, Varmus, H E, de Lange, T
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231372/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8668193/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.7.3765
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