Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.

Activation of telomerase in human cancers is thought to be necessary to overcome the progressive loss of telomeric DNA that accompanies proliferation of normal somatic cells. According to this model, telomerase provides a growth advantage to cells in which extensive terminal sequence loss threatens...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Broccoli, D, Godley, L A, Donehower, L A, Varmus, H E, de Lange, T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231372/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8668193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.7.3765
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