Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha.

Ítems similars

• Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.
  per: Lin, R, et al.
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• A mechanistic insight into a proteasome-independent constitutive inhibitor kappaBalpha (IkappaBalpha) degradation and nuclear factor kappaB (NF-kappaB) activation pathway in WEHI-231 B-cells.
  per: Shumway, Stuart D, et al.
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• Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53.
  per: Wulczyn, F G, et al.
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• IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
  per: Klement, J F, et al.
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