Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha.

Eitemau Tebyg

• Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.
  gan: Lin, R, et al.
  Cyhoeddwyd: (1996)
• An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha.
  gan: Johnson, C, et al.
  Cyhoeddwyd: (1999)
• A mechanistic insight into a proteasome-independent constitutive inhibitor kappaBalpha (IkappaBalpha) degradation and nuclear factor kappaB (NF-kappaB) activation pathway in WEHI-231 B-cells.
  gan: Shumway, Stuart D, et al.
  Cyhoeddwyd: (2004)
• Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53.
  gan: Wulczyn, F G, et al.
  Cyhoeddwyd: (1998)
• IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
  gan: Klement, J F, et al.
  Cyhoeddwyd: (1996)