Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha.

IkappaBalpha is a phosphoprotein that sequesters the NF-kappaB/Rel transcription factors in the cytoplasm by physical association. Following induction by a wide variety of agents, IkappaBalpha is further phosphorylated and degraded, allowing NF-kappaB/Rel proteins to translocate to the nucleus and i...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Schwarz, E M, Van Antwerp, D, Verma, I M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231350/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8668171/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.7.3554
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